Prognostic markers of inflammation in endometrioid and clear cell ovarian cancer.
Alejandro GallegoMarta MendiolaBarbara HernandoAlberto BerjonAlice CadizBlas Chaves-UrbanoVictoria Heredia-SotoEmanuela SpagnoloAlicia Hernández GutiérrezDavid HardissonGeoff MacintyreAndres RedondoMaria Jose GarciaPublished in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2022)
In this study, patients with endometrioid and clear cell ovarian cancer with moderate to high CD8+ and CD3+ intraepithelial tumor infiltrating lymphocytes had longer overall survival. Higher expression of intratumoral CD3+ and CD8+ tumor infiltrating lymphocytes also showed an improved outcome in endometrioid ovarian cancer. In contrast, systemic inflammation, evaluated by neutrophil-to-lymphocyte ratio or presence of endometriosis, did not have a prognostic impact in these histologic subtypes.