Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia.

Agata SakowiczMichalina LisowskaLidia Biesiada Elżbieta Płuciennik Agnieszka GachMagda Rybak-KrzyszkowskaHubert HurasBartosz SakowiczHanna RomanowiczAgnieszka Wanda Piastowska Ciesielska Wojciech HorzelskiTadeusz Pietrucha

Published in: Disease markers (2019)

The depletion of the NEMO protein in the cellular compartments of placental samples may activate one of the molecular pathways influencing the development of preeclampsia, especially in pregnancies with a female fetus. A reduction of the NEMO protein in the nuclear fraction of preeclamptic placentas may intensify the inflammatory state characteristic for preeclampsia and increase the level of apoptosis and necrosis within preeclamptic placentas.

Keyphrases

pregnancy outcomes
early onset
binding protein
protein protein
oxidative stress
preterm birth
amino acid
poor prognosis
pregnant women
cell death
endoplasmic reticulum stress
small molecule
single molecule
gestational age