Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancer.

Svetlana BortnikBasile Tessier-CloutierSamuel LeungJing XuKarama AslehSamantha BuruguJamie MagrillKendall GreeningFatemeh DerakhshanStephen YipTony NgKaren A GelmonTorsten O NielsenSharon M Gorski

Published in: Breast cancer research and treatment (2020)

ATG4B levels varied across breast cancer subtypes but did not show prognostic significance. High LC3B expression and high GABARAP expression were both associated with poor prognosis and with clinicopathological characteristics of aggressive disease phenotypes in all breast cancer subtypes.

Keyphrases

poor prognosis
long non coding rna
cell death
simultaneous determination
mass spectrometry
binding protein
young adults
breast cancer risk
solid phase extraction
high resolution mass spectrometry