Co-culture models of endothelial cells, macrophages, and vascular smooth muscle cells for the study of the natural history of atherosclerosis.

Martin LiuSaurabhi SamantCharu Hasini VasaRyan M PedrigiUsama M OguzSangjin RyuTimothy WeiDaniel R AndersonDevendra K AgrawalYiannis S Chatzizisis

Published in: PloS one (2023)

We present three-cell co-culture models of human atherosclerosis. These models have the potential to allow cost- and time-effective investigations of the mechanobiology of atherosclerosis and new anti-atherosclerotic drug therapies.

Keyphrases

endothelial cells
vascular smooth muscle cells
cardiovascular disease
angiotensin ii
single cell
high glucose
cell therapy
emergency department
type diabetes
mesenchymal stem cells
risk assessment
drug induced
adverse drug
pluripotent stem cells