The role of hsa-miR-193a-5p as an important factor for control of inositol in alopecia areata.

Ahmed Ibrahim AbdElneamMohammed Saleh Al-DhubaibiSaleh Salem BahajGhada Farouk MohammedLina Mohammed Atef

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)

For the first time, our study demonstrates the significant over-expression of a new miRNA, hsa-miR-193a-5p, in the blood of AA patients compared to controls, and highlights its impact on the IPPK gene and the inositol phosphorylation and Phosphatidylinositol signaling pathways, suggesting a potential therapeutic role for hsa-miR-193a-5p in AA.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
signaling pathway
poor prognosis
protein kinase
copy number
epithelial mesenchymal transition
patient reported outcomes
dna methylation
genome wide identification