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Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction.

Chanichon ChomchoeiJames Michael BrimsonSirikalaya Brimson
Published in: Expert opinion on therapeutic targets (2023)
Fluoxetine may have the potential for acute leukemia treatment. Co-treatment with a σ1-R antagonist increases fluoxetine-induced apoptosis, possibly targeting AKT phosphorylation and autophagy activation.
Keyphrases
  • endoplasmic reticulum stress
  • induced apoptosis
  • signaling pathway
  • oxidative stress
  • cell death
  • cell proliferation
  • poor prognosis
  • combination therapy
  • replacement therapy
  • pi k akt
  • binding protein