Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction.

Chanichon Chomchoei James Michael Brimson Sirikalaya Brimson

Published in: Expert opinion on therapeutic targets (2023)

Fluoxetine may have the potential for acute leukemia treatment. Co-treatment with a σ1-R antagonist increases fluoxetine-induced apoptosis, possibly targeting AKT phosphorylation and autophagy activation.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
signaling pathway
oxidative stress
cell death
cell proliferation
poor prognosis
combination therapy
replacement therapy
pi k akt
binding protein