Yolk sac steps up to the plate.

Published in: The Journal of experimental medicine (2022)

Atkins et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211924) create a PSC differentiation model for human yolk sac hematopoiesis and discover multipotent progenitors with erythro-myeloid and T lymphoid potential. The multipotent progenitors emerge via hemogenic endothelium and share origin with primitive erythroid wave in KDR+CD235a/b+ mesoderm.

Keyphrases

pluripotent stem cells
endothelial cells
nitric oxide
bone marrow
dendritic cells
induced pluripotent stem cells
acute myeloid leukemia
climate change