HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC).

Wenhui WangYan ChenLiang WuYi ZhangSeungyeul YooQuan ChenShiping LiuYong HouXiao-Ping ChenQian ChenJun Zhu

Published in: BMC medical genomics (2022)

Our HGE-scSeq data reveals high heterogeneity of HCC tumor cells in terms of both HBV integrations and CNVs. There were two HBV integration hotspots across cells, and cells from multiple tumor sites shared some HBV integration and CNV patterns.

Keyphrases

hepatitis b virus
single cell
liver failure
rna seq
high throughput
induced apoptosis
electronic health record
gene expression
dna methylation
genome wide
artificial intelligence
deep learning
data analysis