Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.
Bastien MassonHélène Le RibeuzJessica SabourinLoann LaubryEmily WoodhouseRichard FosterYann RuchonMary DutheilAngèle BoëtMaria-Rosa GhignaVincent Thomas De MontprevilleOlaf MercierDavid J BeechJean-Pierre BenitahMarc A BaileyMarc HumbertI David MontaniVéronique CapuanoFabrice AntignyPublished in: Circulation research (2022)
In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.