Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions.
Binsheng GongDan LiRebecca KuskoNatalia NovoradovskayaYifan ZhangShangzi WangCarlos Pabón-PeñaZhihong ZhangKevin LaiWanshi CaiJennifer S LoCocoEric LaderTodd A RichmondVinay K MittalLiang-Chun LiuDonald J JohannJames C WilleyPierre R BushelYing YuChang XuGuangchun ChenDaniel BurgessSimon CawleyKristina GiordaNathan HaseleyFujun QiuKatherine WilkinsHanane AribClaire AttwoollKevin BabsonLonglong BaoWenjun BaoAnne Bergstrom LucasHunter BestAmbica BhandariHalil BisginJames BlackburnThomas M BlomquistLisa BoardmanBlake BurgherDaniel J ButlerChia-Jung ChangAlka ChaubeyTao ChenMarco ChiericiChristopher R ChinDevin CloseJeffrey ConroyJessica Cooley ColemanDaniel J CraigErin CrawfordAngela Del PozoIra W DevesonDaniel DuncanAgda Karina EterovicXiaohui FanJonathan FooxCesare FurlanelloAbhisek GhosalSean GlennMeijian GuanChristine HaagXinyi HangScott HappeBrittany HenniganJennifer HippHuixiao HongKyle HorvathJianhong HuLi-Yuan HungMirna JaroszJennifer KerkhofBenjamin KippDavid Philip KreilPaweł ŁabajPablo LapunzinaPeng LiQuan-Zhen LiWeihua LiZhiguang LiYu LiangShaoqing LiuZhichao LiuCharles MaNarasimha MarellaRubén Martín-ArenasDalila B MegherbiQingchang MengPiotr A MieczkowskiTom MorrisonDonna MuznyBaitang NingBarbara L ParsonsCloud P PaweletzMehdi PiroozniaWubin QuAmelia RaymondPaul RindlerRebecca RinglerBekim SadikovicAndreas SchererEgbert SchulzeRobert SebraRita ShaknovichQiang ShiTieliu ShiJuan Carlos Silla-CastroMelissa SmithMario Solís LópezPing SongDaniel StetsonMaya StrahlAlan StuartJulianna SuppleePhilippe SzankasiHaowen TanLin-Ya TangYonghui TaoShraddha ThakkarDanielle Thierry-MiegJean Thierry-MiegVenkat J ThodimaDavid ThomasBoris TichýNikola TomElena Vallespin GarciaSuman VermaKimbley WalkerCharles WangJunwen WangYexun WangZhining WenValtteri WirtaLeihong WuChunlin XiaoWenzhong XiaoShibei XuMary YangJianming YingShun H YipGuangliang ZhangSa ZhangMeiru ZhaoYuanting ZhengXiaoyan ZhouChristopher E MasonTimothy MercerWeida TongLeming ShiWendell JonesJoshua XuPublished in: Genome biology (2021)
This comprehensive study provides actionable guidelines for oncopanel sequencing and clear evidence that supports a simplified approach to assess the analytical performance of oncopanels. It will facilitate the rapid implementation, validation, and quality control of oncopanels in clinical use.