A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9.

Yuqiang QianDi WangWenchao NiuDing ZhaoJinze LiZhiquan LiuXun GaoYang HanLiangxue LaiZhanjun Li

Published in: BMC biology (2023)

We have developed a substantially smaller sABE system that expands the targeting scope and offers higher precision of genome editing. Our findings suggest that the sABE system holds great therapeutic potential in preclinical applications.

Keyphrases

genome editing
crispr cas
cancer therapy
low cost
bone marrow