ASPM Activates Hedgehog and Wnt Signaling to Promote Small Cell Lung Cancer Stemness and Progression.

Li-Hsin Cheng Chung-Chi Hsu Hung-Wen Tsai Wen-Ying Liao Pei-Ming Yang Tai-Yan Liao Hsiao-Yen Hsieh Tze-Sian Chan Kelvin K Tsai

Published in: Cancer research (2023)

ASPM promotes SCLC stemness and aggressiveness by stabilizing the expression of GLI1, DVL3, and SMO, representing a novel regulatory hub of Hh and Wnt signaling and targetable vulnerability.

Keyphrases

small cell lung cancer
stem cells
epithelial mesenchymal transition
poor prognosis
climate change
cancer stem cells
transcription factor
network analysis
binding protein
signaling pathway
long non coding rna