Argenteolides A and B, Glycosylated Polyketide-Peptide Hybrid Macrolides from an Actinomycete Streptomyces argenteolus .
Zhiguo LiuYoko YashirodaPeng SunHai MaYa-Nan WangLi LiFu YanYi SunPublished in: Organic letters (2022)
Two novel glycosylated polyketide-peptide hybrid macrolides, argenteolides A ( 1 ) and B ( 2 ), were isolated from an actinomycete Streptomyces argenteolus . Argenteolide A ( 1 ) contains a unique 5/5/5 tricyclic system in a 20-membered macrocycle. Their structures were elucidated by extensive spectroscopic analysis, and their stereochemical configurations were established through the application of chemical derivatization, J -based configuration analysis, DP4+ calculation, and electronic circular dichroism calculation. The analysis of the genome sequence revealed a plausible biosynthesis mechanism, and isotope-labeled feeding studies suggested their biogenetic origins. Argenteolides A and B exhibited moderate cytotoxicities against A549, p388, and Hela human carcinoma cell lines as well as antibacterial activities against Staphylococcus aureus and Escherichia coli ATCC25922.
Keyphrases
- escherichia coli
- staphylococcus aureus
- endothelial cells
- molecular docking
- ms ms
- high resolution
- genome wide
- cell proliferation
- dna methylation
- mass spectrometry
- computed tomography
- gas chromatography
- liquid chromatography
- amino acid
- high intensity
- high performance liquid chromatography
- induced pluripotent stem cells
- cell wall
- pluripotent stem cells
- wound healing
- pet ct