Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.
Anurag VermaJennifer E HuffmanAlex RodriguezMitchell ConeryMolei LiuYuk-Lam Anne HoYoungdae KimDavid A HeiseLindsay GuareVidul Ayakulangara PanickanHelene GarconFranciel LinaresLauren CostaIan GoethertRyan TiptonJacqueline HonerlawLaura DaviesStacey WhitbourneJeremy CohenDaniel C PosnerRahul SangarMichael MurrayXuan WangDaniel R DochtermannPoornima DevineniYunling ShiTarak Nath NandiThemistocles L AssimesCharles A BrunetteRobert J CarrollRoyce CliffordScott DuvallJoshua C GrayAdriana HungSudha K IyengarJacob JosephRachel L KemberHenry KranzlerDaniel LeveyShiuh-Wen LuohVictoria C MerrittCassie OverstreetJoseph D DeakStruan F A GrantRenato PolimantiPanos RoussosYan V SunSanan VenkateshGeorgios VoloudakisAmy JusticeEdmon BegoliRachel RamoniGeorgia TourassiSaiju PyarajanPhilip S TsaoChristopher J O'DonnellSumitra MuralidharJennifer MoserJuan P CasasAlexander G BickWei ZhouTianxi CaiBenjamin F VoightKelly ChoMichael J GazianoRavi K MadduriScott M DamrauerKatherine P LiaoPublished in: medRxiv : the preprint server for health sciences (2023)
To address the underrepresentation of non-European individuals in genome-wide association studies (GWAS), we conducted a population-stratified phenome-wide GWAS across 2,068 traits in 635,969 participants from the diverse U.S. Department of Veterans Affairs Million Veteran Program, with results expanding our knowledge of variant-trait associations and highlighting the importance of genetic diversity in understanding the architecture of complex health and disease traits.