Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts.
Chuen-Mao YangChien-Chung YangLi-Der HsiaoChia-Ying YuHui-Ching TsengChih-Kai HsuJiro Hasegawa SitumorangPublished in: Journal of inflammation research (2021)
Our results suggested that TNF-α-induced COX-2/PGE2 upregulation is mediated through TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs.
Keyphrases
- signaling pathway
- transcription factor
- pi k akt
- rheumatoid arthritis
- induced apoptosis
- endothelial cells
- poor prognosis
- cell death
- high glucose
- cell proliferation
- diabetic rats
- left ventricular
- heart failure
- induced pluripotent stem cells
- protein kinase
- oxidative stress
- binding protein
- extracellular matrix
- atrial fibrillation
- long non coding rna
- stress induced