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Age at puberty and risk of asthma: A Mendelian randomisation study.

Cosetta MinelliDiana A van der PlaatBénédicte LeynaertRaquel GranellAndre F S AmaralMiguel PereiraOsama MahmoudJames PottsNuala A SheehanJack BowdenJohn ThompsonDeborah L JarvisGeorge Davey SmithJohn Henderson
Published in: PLoS medicine (2018)
This large MR study provides evidence for a causal detrimental effect of early puberty on asthma, and does not support previous observational findings of a U-shaped relationship between pubertal timing and asthma. Common biological or psychological mechanisms associated with early puberty might explain the similarity of our results in females and males, but further research is needed to investigate this. Taken together with evidence for other detrimental effects of early puberty on health, our study emphasises the need to further investigate and address the causes of the secular shift towards earlier puberty observed worldwide.
Keyphrases
  • chronic obstructive pulmonary disease
  • healthcare
  • lung function
  • public health
  • magnetic resonance
  • magnetic resonance imaging
  • cross sectional
  • physical activity
  • climate change
  • social media