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Sodium Trifluoroacetate mediated Copper-Catalyzed aza -Michael addition of α,β -unsaturated olefins with aromatic amines.

S Erfan MasaeliMohsen TeimouriBhupendra AdhikariMahshid AttarroshanJames W AkinSelvam RajuSean L StokesJoseph P Emerson
Published in: Tetrahedron letters (2023)
We present a sodium trifluoroacetate (CF 3 CO 2 Na) mediated copper-catalyzed aza -Michael addition of aromatic amines with activated olefins under mild, aqueous reaction conditions. This simplistic protocol employs a copper catalyst (10 mol%) and water as solvent. This transformation occurs precisely with aromatic substituted amines containing both electron-donating (EDG) and electron-withdrawing (EWG) groups. A broad range of substrates were tested under the optimized conditions, which are producing good to moderate yields.
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