Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial.
Adrien BougléSophie TuffetLaura FedericiMarc LeoneAntoine MonselThomas DessalleJulien AmourClaire Dahyot-FizelierFrançois BarbierCharles-Edouard LuytOlivier LangeronBernard CholleyJulien PottecherTarik HissemJean-Yves LefrantBenoit VeberMatthieu LegrandAlexandre DemoulePierre KalfonJean-Michel ConstantinAlexandra RousseauTabassome SimonArnaud Foucriernull nullPublished in: Intensive care medicine (2022)
Our study failed to show the non-inferiority of a short duration of antibiotics in the treatment of PA-VAP, compared to a long duration. The short duration strategy may be associated to an increase of PA-VAP recurrence. However, the lack of power limits the interpretation of this study.