Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial.
Marie Joyeux-FaureRenaud TamisierJean-Philippe BaguetSonia Dias-DomingosStephen PerrigGeorges LeftheriotisJean-Paul JanssensWojciech TrzepizurSandrine H LaunoisFrançoise Stanke-LabesquePatrick A LévyFrédéric GagnadouxJean-Louis PepinPublished in: Mediators of inflammation (2014)
In OSA patients, 3 months of atorvastatin neither improved endothelial function nor reduced early signs of atherosclerosis although it lowered blood pressure and improved lipid profile. This trial is registered with NCT00669695.
Keyphrases
- obstructive sleep apnea
- randomized controlled trial
- blood pressure
- study protocol
- end stage renal disease
- cardiovascular disease
- newly diagnosed
- positive airway pressure
- ejection fraction
- chronic kidney disease
- clinical trial
- prognostic factors
- coronary artery disease
- stem cells
- phase iii
- metabolic syndrome
- systematic review
- hypertensive patients
- patient reported outcomes
- weight loss
- adipose tissue
- sleep apnea
- phase ii
- skeletal muscle
- blood glucose