Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy.

Graham S DonenZoe WhiteElodie SaugeMorten RitsoMarine TheretJohn BoydAngela M DevlinFabio M V RossiPascal Bernatchez

Published in: Muscle & nerve (2022)

TN and WD combination exacerbates rodent LGMD2b without affecting WT mice. This improves rodent modeling of human MD and helps elucidate how metabolic abnormalities may play a causal role in muscle wasting.

Keyphrases

muscular dystrophy
endothelial cells
duchenne muscular dystrophy
physical activity
skeletal muscle
weight loss
south africa
molecular dynamics
induced pluripotent stem cells
pluripotent stem cells
high fat diet induced
type diabetes
adipose tissue
mental health