HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B*58:01 carriers in a Korean population; a multicenter cross-sectional case-control study.
Mi-Yeong KimJames YunDong Yoon KangTae Hee KimMin-Kyung OhSunggun LeeMin-Gyu KangYoung-Hee NamJeong-Hee ChoiMin-Suk YangSeung Seok HanHajeong LeeHyun-Jai ChoJaeseok YangKook-Hwan OhYon Su KimJae Woo JungKye-Hwa LeeHye-Ryun KangPublished in: Clinical and translational allergy (2022)
The additional secondary screening with A*24:02 and DRB1*13:02 alleles may identify those at further increased risk of allopurinol-induced DRESS in B*58:01 carriers.