Use of subgroup-specific hematopoietic stem cell collection efficiencies to improve truncation calculations for large-volume leukapheresis procedures.
Kai J RogersSarah L MottMeredith G ParsonsAnnette J SchlueterPublished in: Journal of clinical apheresis (2023)
Individualized CE does not substantially improve truncation volume calculations over use of a fixed CE and adds complexity to these calculations. The optimal fixed CE varies between autologous and allogeneic donors, and donors with high pre-collection PB cell counts in either of these groups. This model will be clinically validated and continuously refined through analysis of future HSC collections.
Keyphrases
- hematopoietic stem cell
- density functional theory
- molecular dynamics
- molecular dynamics simulations
- monte carlo
- cell therapy
- energy transfer
- bone marrow
- stem cell transplantation
- single cell
- kidney transplantation
- heavy metals
- current status
- stem cells
- clinical trial
- peripheral blood
- risk assessment
- low dose
- mesenchymal stem cells
- platelet rich plasma
- randomized controlled trial
- high dose
- phase iii