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A saltationist theory of cancer evolution.

Florian Markowetz
Published in: Nature genetics (2017)
A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.
Keyphrases
  • copy number
  • mitochondrial dna
  • genome wide
  • dna methylation
  • papillary thyroid
  • squamous cell carcinoma
  • squamous cell
  • gene expression
  • childhood cancer
  • adverse drug