Blockage of Wnt/β-catenin Signaling Pathway in Colorectal Cancer Resistant Cells by Nitazoxanide Effects on Peptidylarginine Deiminases Expression.

Mohsen Hemmati-DinarvandShahnaz KheirandishAli KhodadadianMostafa MostafazadehAtefeh Seghatoleslam

Published in: Asian Pacific journal of cancer prevention : APJCP (2022)

The results showed that NTZ leads to notable upregulation of PAD2 and PAD4, which can disrupt the Wnt/β-catenin signaling pathway and reverse the MDR by reducing MDR1 and MRP1 expression.

Keyphrases

poor prognosis
cell proliferation
multidrug resistant
stem cells
induced apoptosis
long non coding rna
binding protein
cell cycle arrest
signaling pathway
pi k akt