Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma.
Charles Ching Lick TongMateusz KoptyraPichai RamanKomal S RathiNamrata ChoudhariXiang LinTyler SeckarZhi WeiMichael A KohanskiBert W O'MalleyNoam A CohenDavid W KennedyNithin D AdappaErle S RobertsonEsther BaranovEdward Cheng-Lung KuanPeter PapagiannopoulosJalal B JalalyMichael D FeldmanPhillip B StormAdam C ResnickJames N PalmerPublished in: International forum of allergy & rhinology (2021)
Progressive upregulation of genes specific to IP malignant degeneration has significant clinical implications. This panel of 11 genes will improve concordance of histologic classification, which can directly impact treatment and patient outcomes. Additionally, future studies on larger tumor sets may observe upregulation in the gene panel that preceded histologic changes, which may be useful for further risk stratification.
Keyphrases
- genome wide
- genome wide identification
- gene expression
- squamous cell carcinoma
- dna methylation
- poor prognosis
- cell proliferation
- genome wide analysis
- bioinformatics analysis
- signaling pathway
- multiple sclerosis
- machine learning
- copy number
- transcription factor
- current status
- cancer therapy
- locally advanced
- combination therapy
- long non coding rna
- case control
- smoking cessation