A real-world study of second or later-line osimertinib in patients with EGFR T790M-positive NSCLC: the final ASTRIS data.
Parneet CheemaByoung Chul ChoHelano FreitasMariano ProvencioYuh Min ChenSang-We KimYi-Long WuAntonio PassaroClaudio MartinMarcello TiseoGee-Chen ChangKeunchil ParkBenjamin SolomonOtto BurghuberJanessa LaskinZiping WangSung Yong LeeYanping HuJohan VansteenkisteHe-Long ZhangEmer HanrahanThomas GeldartRosemary TaylorLeslie ServidioJingyi LiFilippo de MarinisPublished in: Future oncology (London, England) (2023)
Aim: Report the final analysis from ASTRIS, the largest real-world study of second-/later-line osimertinib in advanced/metastatic EGFR T790M non-small-cell lung cancer (NSCLC). Methods: Patients with advanced/metastatic EGFR T790M NSCLC and prior EGFR-TKI treatment, received once-daily osimertinib 80 mg. Primary end point: overall survival (OS); secondary end points: progression-free survival (PFS), time-to-treatment discontinuation (TTD) and response rate. Safety was also recorded. Results: In 3014 patients, median OS: 22.8 months (21.6-23.8), median PFS: 11.1 months (11.0-12.0), median TTD: 13.5 months (12.6-13.9), and response rate: 57.3% (55.5-59.2). All end points reported with 95% CIs . Numerically longer median OS was observed in patients with baseline WHO performance status <2 versus 2 (24.0 vs 11.1 months) and those without versus with brain/leptomeningeal metastases (25.4 vs 18.0 months). No new safety signals were identified. Conclusion: Second-/later-line osimertinib demonstrated real-world clinical benefit and safety in advanced/metastatic EGFR T790M NSCLC. Clinical Trial Registration: NCT02474355 (ClinicalTrials.gov).
Keyphrases
- small cell lung cancer
- brain metastases
- epidermal growth factor receptor
- advanced non small cell lung cancer
- free survival
- clinical trial
- tyrosine kinase
- end stage renal disease
- newly diagnosed
- ejection fraction
- squamous cell carcinoma
- randomized controlled trial
- prognostic factors
- machine learning
- open label
- patient reported outcomes
- cerebral ischemia