Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
Pratik SinhaLucile P A NeytonAartik SarmaNelson WuChayse JonesHanjing ZhuoKathleen D LiuEstella Sanchez GuerreroRajani GhaleChristina LoveEran MickKevin L DelucchiCharles R LangelierB Taylor ThompsonMichael A MatthayCarolyn S Calfeenull nullPublished in: American journal of respiratory and critical care medicine (2024)
The Hyperinflammatory and Hypoinflammatory phenotypes have different clinical, protein, and dynamic transcriptional characteristics. These findings support the clinical and biological potential of molecular phenotypes to advance precision care in ARDS.
Keyphrases
- gene expression
- acute respiratory distress syndrome
- healthcare
- extracorporeal membrane oxygenation
- mechanical ventilation
- dna methylation
- palliative care
- clinical trial
- study protocol
- quality improvement
- randomized controlled trial
- intensive care unit
- risk assessment
- oxidative stress
- adipose tissue
- metabolic syndrome
- phase iii
- pain management
- protein protein
- human health
- skeletal muscle
- binding protein
- amino acid
- weight loss