Met166 -Glu168 residues in human PrP β2-α2 loop account for evolutionary resistance to prion infection.
Juan Carlos EspinosaAlba Marín-MorenoPatricia Aguilar-CalvoJuan-Maria TorresPublished in: Neuropathology and applied neurobiology (2020)
Met166 -Glu168 amino acid residues present in wild-type human PrPC are molecular determinants that limit the propagation of most prion strains assayed in the human PrP context.