Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.
Nikhil VergisWafa KhamriKylie BealeFouzia SadiqMina O AletrariCelia MooreStephen R AtkinsonChristine BernsmeierLucia A PossamaiGemma PettsJennifer M RyanRobin D AbelesSarah JamesMatthew FoxtonBrian HoganGraham R FosterAlastair J O'BrienYun MaDebbie L ShawcrossJulia A WendonCharalambos G AntoniadesMark R ThurszPublished in: Gut (2016)
Monocyte oxidative burst and bacterial killing is impaired in alcoholic hepatitis while bacterial uptake by phagocytosis is preserved. Defective MOB is associated with reduced expression of NADPH oxidase in these patients and predicts the development of infection and death.