Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.

Domenico MotolaMonia DonatiChiara BiagiElisabetta CalamelliFrancesca CiprianiMauro MelisLuca MonacoAlberto VaccheriGiampaolo Ricci

Published in: Pharmacoepidemiology and drug safety (2017)

H1-antihistamines are among the most used drugs in pediatrics, also in an off-label manner. Our data highlights associations with serious and unexpected ADRs. Educative intervention to clinicians and parents are needed to help doctors to make proper choices on the drug treatment and for the early detection of ADRs to maximize the benefits and reduce the risk of ADRs in these patients.

Keyphrases

end stage renal disease
electronic health record
newly diagnosed
randomized controlled trial
chronic kidney disease
big data
prognostic factors
palliative care
peritoneal dialysis
artificial intelligence
machine learning
patient reported outcomes