Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Mirela Georgiana PerneAdela-Viviana Sitar-TăutTeodora Gabriela AlexescuLorena CiumărneanMircea-Vasile MilaciuSorina-Cezara CosteCalin-Vasile VladAngela CozmaDan-Andrei Sitar-TăutOlga Hilda OrăşanAlexandra Marioara CraciunPublished in: Diagnostics (Basel, Switzerland) (2023)
a total number of 37 studies (5037 patients with HCC vs. 8199 patients-control group) have been included in the meta-analysis. PIVKA II presented a better diagnostic accuracy in HCC diagnostic vs. alpha-fetoprotein (global PIVKA II AUROC 0.851 vs. AFP AUROC 0.808, respectively, 0.790 vs. 0.740 in early HCC cases). The conclusion from a clinical point of view, concomitant use of PIVKA II and AFP can bring useful information, added to that brought by ultrasound examination.