The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis.

Soji TaniKoji IshikawaYoshifumi KudoKoki TsuchiyaAkira MatsuokaHiroshi MaruyamaHaruka EmoriRyo YamamuraChikara HayakawaMasaya SekimizuYusuke OshitaTomoyuki OzawaToshiyuki ShirahataTakashi NagaiTomoaki ToyoneKatsunori Inagaki

Published in: Journal of orthopaedic surgery and research (2021)

To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis.

Keyphrases

bone mineral density
minimally invasive
postmenopausal women
finite element analysis
giant cell
spinal cord
body composition
cross sectional
genome wide
coronary artery disease
spinal cord injury
middle aged
single cell
acute coronary syndrome