Food antigen consumption and disease activity affect food-specific IgG4 levels in patients with eosinophilic esophagitis (EoE).
Emily C McGowanJonathan MedernachBehnam KeshavarzLisa J WorkmanRung-Chi LiBarrett H BarnesBryan SauerJeffrey M WilsonThomas A E Platts-MillsPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)
Serum sIgG4 levels to food and aeroallergen proteins were higher in patients with EoE than non-EoE controls, and higher levels of milk sIgG4 were independently associated with milk consumption and the presence of sIgE to milk proteins. Whether sIgG4 plays a pathogenic role in EoE or could be used as an EoE biomarker remains unknown and warrants further study.