TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.
Tetsuo TaniHaritha MathsyarajaMarco CampisiZe-Hua LiKoji HarataniCaroline G FaheyKeiichi OtaNavin R MahadevanYingxiao ShiShin SaitoKei MizunoTran C ThaiNobunari SasakiMizuki HommeChoudhury Fabliha B YusufAdam KashishianJipsa PanchalMin WangBenjamin J WolfThanh U BarbieCloud P PaweletzPrafulla C GokhaleDavid R LiuRavindra UppaluriShunsuke KitajimaJennifer CainDavid A BarbiePublished in: Cancer discovery (2024)
STING-IFN signaling in cancer cells promotes tumor cell immunogenicity. Inactivation of the DNA exonuclease TREX1, which is adaptively upregulated to limit pathway activation in cancer cells, recruits immune effector cells and primes NK cell-mediated killing. Targeting TREX1 has substantial therapeutic potential to amplify cancer cell immunogenicity and overcome ICB resistance. This article is featured in Selected Articles from This Issue, p. 695.