Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains.

Carla C C R de CarvalhoAgustina TaglialegnaAdriana E Rosato

Published in: The Journal of antimicrobial chemotherapy (2021)

Our findings show that PrsA, in addition to its post-transcriptional role in the maturation of PBP 2a, is a key mediator of cell membrane remodelling connected to the see-saw effect and may have a key role in the resensitization of daptomycin-resistant strains to β-lactams, such as oxacillin.

Keyphrases

methicillin resistant staphylococcus aureus
escherichia coli
staphylococcus aureus
gene expression
transcription factor
fatty acid
heat shock
gram negative