Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase II Randomized, Placebo-Controlled Trial.

Kathrine Kronberg Jakobsen Amanda-Louise Fenger Carlander Tobias Todsen Jacob Melchiors Natasja Paaske Anne Kathrine Østergaard Madsen Simone Kloch Bendtsen Christine Mordhorst Helene Stampe Jens Kastrup Annette Ekblond Mandana Haack-Sørensen Mohammad Farhadi Christian Maare Jeppe Friborg Charlotte Duch Lynggaard Anne Werner Hauge Robin Christensen Christian Grønhøj Larsen Christian von Buchwald

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We could not confirm superiority of the ASC relative to placebo. ASC therapy significantly improved UWS in previous patients with head and neck cancer, whereas placebo resulted in an insignificant increase.

Keyphrases

double blind
phase ii
cell therapy
radiation induced
placebo controlled
clinical trial
stem cells
phase iii
bone marrow
radiation therapy
mesenchymal stem cells
nlrp inflammasome
open label
study protocol
randomized controlled trial