Down-regulation of stimulator of interferon genes (STING) expression and CD8 + T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.

Satoshi FukaiShotaro NakajimaMotonobu SaitoKatsuharu SaitoKoji KaseHiroshi NakanoTakahiro SatoMei SakumaAkinao KanetaHirokazu OkayamaKosaku MimuraWataru SakamotoZenichiro SazeTomoyuki MommaKoji Kono

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

Our results suggest that HER2 signaling might suppress immune cell activation in the GC TME by inhibiting STING signaling in tumor cells in HER2-positive GC.

Keyphrases

poor prognosis
signaling pathway
dendritic cells
gas chromatography
single cell
immune response
bioinformatics analysis
genome wide identification