Animal models for studying the etiology and treatment of low back pain.
Changgui ShiSujun QiuScott M RiesterVaskar DasBingqian ZhuAtiyayein A WallaceAndre J van WijnenFackson MwaleJames C IatridisDaisuke SakaiGina Votta-VelisWen YuanHee-Jeong ImPublished in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2018)
Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1305-1312, 2018.
Keyphrases
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- chronic kidney disease
- chronic pain
- peritoneal dialysis
- prognostic factors
- neuropathic pain
- randomized controlled trial
- oxidative stress
- spinal cord
- climate change
- high glucose
- risk assessment
- social media
- drug induced
- postoperative pain
- human health
- replacement therapy
- health information