Inhibition of proprotein convertases activity results in repressed stemness and invasiveness of cancer stem cells in gastric cancer.

Anissa ZaafourLornella SeeneevassenTra Ly NguyenCoralie GenevoisNour NicolasElodie SifréAlban GieseChloé PorcheronJean DescarpentriePierre DubusAbdel-Majid KhatibChristine Varon

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)

PCs are overexpressed in GC and associated with poor prognosis. PCs are involved in the malignant and metastatic potential of CSCs via the regulation of EMT, the YAP/TAZ/TEAD oncogenic pathway, and their stemness and invasive properties. Their repression represents a new strategy to target CSCs and impair metastatic spreading in GC.

Keyphrases

cancer stem cells
poor prognosis
long non coding rna
squamous cell carcinoma
small cell lung cancer
epithelial mesenchymal transition
gas chromatography
transcription factor
mass spectrometry
climate change
tandem mass spectrometry
simultaneous determination