Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study.

Christine Johnston Amalia S Magaret Pavitra Roychoudhury Alexander L Greninger Daniel B ReevesJoshua SchifferKeith R JeromeCassandra SatherKurt DiemJairam R LingappaConnie CelumDavid M Koelle Anna Wald

Published in: PLoS medicine (2017)

HSV-2 dual-strain infection was detected in 3.7% of paired samples from individual participants, and was more frequent among people with HIV infection. Simulations suggest that the true prevalence of dual-strain infection is 7%. Our data indicate that naturally occurring immunity to HSV-2 may be protective against infection with a second strain. This study is limited by the inability to determine the timing of acquisition of the second strain.

Keyphrases

herpes simplex virus
risk factors
sars cov
machine learning
molecular dynamics
dna methylation
high throughput
genome wide
antiretroviral therapy
single cell
data analysis