Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.

Hannah Gilliam-Vigh Tina Jorsal Sophie W Nielsen Julie Lyng Forman Jens Pedersen Steen Seier Poulsen Tina Vilsbøll Filip K Krag Knop

Published in: The Journal of clinical endocrinology and metabolism (2023)

SCT and SCTR mRNA expression and S cell density were abundant in the duodenum and decreased along the small intestine. Very low SCT and SCTR mRNA levels and S cell numbers were observed in the large intestine; without aberrations in individuals with T2D compared to healthy controls.

Keyphrases

type diabetes
single cell
end stage renal disease
cell therapy
newly diagnosed
ejection fraction
binding protein
chronic kidney disease
cardiovascular disease
poor prognosis
prognostic factors
adipose tissue
stem cells
insulin resistance
metabolic syndrome
weight loss
skeletal muscle