Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.

Xiong-Zhi LiZhuo-Chao XiongShao-Ling ZhangQing-Yun HaoZhao-Yu LiuHai-Feng ZhangJing-Feng WangJing-Wei GaoPin-Ming Liu

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our study clarifies a novel mechanism by which upregulation of H19 contributes to aldosterone-MR complex-promoted Runx2-dependent VSMC osteogenic differentiation and VC through sponging miR-106a-5p. These findings highlight a potential therapeutic target for aldosterone-induced VC.

Keyphrases

high glucose
angiotensin ii
diabetic rats
transcription factor
mesenchymal stem cells
drug induced
poor prognosis
magnetic resonance
long non coding rna
chronic kidney disease
endothelial cells
oxidative stress
human health