Can metformin relieve tibiofemoral cartilage volume loss and knee symptoms in overweight knee osteoarthritis patients? Study protocol for a randomized, double-blind, and placebo-controlled trial.

Guangfeng RuanShiwen YuanAiju LouYingqian MoYuan QuDongmei GuoShangqi GuanYan ZhangXiaoyong LanJun LuoYifang MeiHongwei ZhangWeirong WuLie DaiQinghong YuXiaoyan CaiChanghai Ding

Published in: BMC musculoskeletal disorders (2022)

ClinicalTrials. gov NCT05034029 . Registered on 30 Sept 2021.

Keyphrases

knee osteoarthritis
double blind
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
total knee arthroplasty
prognostic factors
study protocol
placebo controlled
randomized controlled trial
body mass index
sleep quality
phase ii