Tamoxifen induced hepatic steatosis in high-fat feeding rats through SIRT1-Foxo1 suppression and LXR-SREBP1c activation.

Miao LiYu CaiXi ChenLuyong Zhang Zhen-Zhou JiangQinwei Yu

Published in: Toxicology research (2022)

Tamoxifen increased lipid synthesis and regulated lipid transport in HFD rat liver.p-FoxO1/LXRα-SREBP1c signaling was upregulated through the inhibition of SIRT1 in tamoxifen-induced hepatic steatosis under HFD condition.SIRT1 agonist SRT1720 could relieve tamoxifen-induced hepatic steatosis.

Keyphrases

diabetic rats
high glucose
oxidative stress
breast cancer cells
estrogen receptor
transcription factor
positive breast cancer
drug induced
high fat diet
type diabetes
signaling pathway
endothelial cells
fatty acid
metabolic syndrome
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