Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients.
Julien PottecherEric NollMarie BorelGérard AudibertSébastien GetteChristian MeyerElisabeth GaertnerVincent LegrosRaphaël CarapitoBéatrice Uring-LambertErik SauleauWalter G LandSeiamak BahramAlain MeyerBernard GenyPierre DiemunschPublished in: Trials (2020)
ClinicalTrials.gov, NCT03368092. Registered on 11 December 2017.
Keyphrases
- trauma patients
- double blind
- placebo controlled
- clinical trial
- study protocol
- phase ii
- randomized controlled trial
- phase iii
- intensive care unit
- risk factors
- acute respiratory distress syndrome
- high intensity
- early onset
- phase ii study
- replacement therapy
- open label
- drug induced
- extracorporeal membrane oxygenation
- radiation therapy
- smoking cessation
- locally advanced