Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury.

Huimin ShiYajie ZhaoTiantian HeXianli WenGaoting QuShanwen LiWeihua Gan Aiqing Zhang

Published in: Molecular biology reports (2022)

We demonstrated that rapamycin attenuated podocyte apoptosis via upregulation of nestin expression through the mTOR/P70S6K signaling pathway in an Ang II-induced podocyte injury.

Keyphrases

high glucose
endothelial cells
signaling pathway
poor prognosis
diabetic nephropathy
oxidative stress
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
diabetic rats
angiotensin ii
pi k akt
cell death
long non coding rna
epithelial mesenchymal transition
drug induced
binding protein