Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution.
Xiansong WangWei HuXiangChun LiDan HuangQing LiHung ChanJudeng ZengChuan XieHuarong ChenXiaodong LiuTony GinMaggie Haitian WangAlfred Sze Lok ChengWei KangKa-Fai ToDariusz PlewczyńskiQingpeng ZhangXiaoting ChenDanny Cheuk Wing ChanHo KoSunny-Hei WongJun YuMatthew Tak Vai ChanLin ZhangWilliam Ka Kei WuPublished in: Cancer research (2022)
This work unveils extensive trafficking of TSGs from the X chromosome to autosomes during evolution, thus identifying X-linked TSGs as a genetic Achilles' heel in tumor suppression.