Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia.
Sean HarropPhillip C NguyenDavid ByrneClarissa WilsonGeorgina L RylandTamia NguyenMary Ann AndersonSeong Lin KhawMichelle MartinIng Soo TiongElaine SanijPiers A BlomberyPublished in: EJHaem (2023)
UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co-mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF-TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF- TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
Keyphrases
- rheumatoid arthritis
- disease activity
- poor prognosis
- acute myeloid leukemia
- liver failure
- long non coding rna
- respiratory failure
- bone marrow
- dendritic cells
- drug induced
- aortic dissection
- intensive care unit
- emergency department
- ulcerative colitis
- hepatitis b virus
- systemic lupus erythematosus
- risk assessment
- immune response
- human health