Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity.

Kyle CurrentCatherine MeyerClara E MagyarChristine E MonaJoel AlmajanoRoger SlavikAndreea D StuparuChloe ChengDavid W DawsonCaius G RaduJohannes CzerninKatharina Lückerath

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

In the current models, both the degree of PSMA expression and the fraction of PSMA+ cells correlate with 177Lu-/225Ac-PSMA617 tumor uptake and DNA damage, and thus, RLT efficacy. Low or heterogeneous PSMA expression represents a resistance mechanism to RLT.See related commentary by Ravi Kumar and Hofman, p. 2774.

Keyphrases

pet ct
pet imaging
dna damage
poor prognosis
stem cells
induced apoptosis
single cell
signaling pathway
cell death
cell cycle arrest
computed tomography
mesenchymal stem cells
endoplasmic reticulum stress
long non coding rna
cell therapy