Cultivation and extraction of the fungus Stereum hirsutum (Willd.) Pers. yielded 12 isopentenyl benzene derivatives, including six previously undescribed derivatives, named stereuins A-F. Their structures were established based on NMR and mass spectroscopy analyses, supplemented by comparison with previously reported data. Stereuins A-C are unique benzoate derivatives containing fatty acid subunits. Stereuins D and E feature a valylene group and a 6/6/6 ring system. In vitro, stereuin A significantly promoted neurite outgrowth. Several compounds exhibited antibacterial activity against Staphylococcus aureus. Stereuin F has an IC 50 value of 5.2 μg/mL against S. aureus, comparable to the positive control, penicillin G sodium (1.4 μg/mL).
Keyphrases
- high resolution
- staphylococcus aureus
- fatty acid
- structure activity relationship
- solid state
- silver nanoparticles
- machine learning
- magnetic resonance
- electronic health record
- deep learning
- genome wide identification
- escherichia coli
- mass spectrometry
- pseudomonas aeruginosa
- methicillin resistant staphylococcus aureus
- transcription factor
- neural network